Studies indicate that high levels of fibrinogen raise the risk of CVD. For example, data from an arm of the Physicians' Health Study disclosed that apparently healthy men with excessive concentrations (343 mg/dL or more) had roughly twice the risk of MI as those with lower fibrinogen levels.20 In this and other studies, fibrinogen proved to be a powerful, independent herald of CHD. In other circumstances, fibrinogen's predictive ability relied on the presence of other risk factors. However, its precise effect on risk has not been quantified. At present, it does not appear to be nearly as important as the established risk factors, and studies have not yet shown that limiting amounts will lower the incidence of CHD.

As with other emerging risk factors, fibrinogen can be brought under control when the traditional risk factors are addressed. Smoking raises fibrinogen levels, and quitting certainly improves them. Similarly, weight loss and exercise are beneficial. Treatment with nutraceuticals include the use of Omega three fatty acids (The DHA subfraction of fish oil is most active) pharmaceuticals which have been shown effective to also lower fibrinogen levels include fenofibrate or ticlopidine .Aspirin use has also been shown to reduces the risk of MI in men with abnormally high concentrations.