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Menopause and Natural Hormone Replacement Therapy

Understanding Menopause - Symptoms Of Menopause

As most women approach menopause, their menstrual periods become irregular - they happen closer together and/or further apart. Other common symptoms include

Symptoms Association With Estrogen Loss
And Onset Of Menopause
(adapted from: Lobo, 1999; Abrams et al., 2000)
Psychological Symptoms Somatic Symptoms Physiological Symptoms
Irritability
Occasional sleeplessness
Mood swings
Depressed mood
Anxiety
Nervousness
Poor concentration
Hot flashes
Profuse sweating
Headache
Vertigo
Palpitations
Loss of skin elasticity
Urogenital atrophy
Incontinence
Weight gain
Most Common Symptoms
Vasomotor Symptoms - commonly known as "Hot Flashes" are experience by 75% of the women in the US. Hot flashes that occur with drenching perspiration are called night sweats this usually results in fragmented sleep patterns associated with menopause.. During a hot flash blood rushed to the skin especially the hands and toes where temperature can rise 1-7degrees C. A sudden wave of heat then spreads all over the body with flushing to facial area, followed by a drop in core body temperatures. Women whom have hot flashes usually have them for 3-5 years but some women can have hot flashes 10 to 20 years after onset of menopause. Hot flashes are usually self-limited over time as the body slowly adapts itself to lower estrogen levels.
Vulva and Vaginal Symptoms - (Urogenital atrophy) Declining estrogen levels causes the tissue of the vagina and urethra (the opening to the bladder) to become thinner, drier, and less elastic. The first symptom is a reduction of vaginal fluid secretions. This dryness is due to diminished blood flow to the vaginal walls, fewer cells lining the walls, less mucus produced by the cervix, and less fluid in general.

Decreased lubrication and dryness will develop early in Perimenopause with the reduction in estrogen levels. Physical changes to the vagina won't occur overnight, and will be less severe in sexually active women. The vaginal walls, in a process called atrophy, become thinner, less elastic and pale. The stretchy wrinkles that provided the amazing expansion required for childbirth smooth out and disappear. Without the usual moisture, the vagina fails to lubricate properly during sexual arousal and intercourse. The thin, less flexible surface can be easily injured by sexual intercourse, especially if it is infrequent.

With the loss of estrogen, the vaginal pH changes from a normally acidic low to a higher, more alkaline pH. This less acidic environment discourages the growth of important protective organisms, lactobacillus that acts as a bacterial guard against abnormal bacteria and yeasts. In the absence of lactobacillus, these "bad guys" overgrow and can cause discharge, irritation, and give rise to increased urinary tract infections.

Skin Tone - Estrogen depletion leads to loss of skin moisture and suppleness, which contributes to sagging, bagging, and wrinkling. Collagen, which is responsible for skin resilience and tone, is at its peak quantity between ages 20 and 40.

Sun damage and smoking can decrease the formation of collagen and, after 40; there is an age related collagen loss. The age-related loss accelerates significantly after menopause, giving rise to dry, flaky "alligator" skin and wrinkles.

Several studies have demonstrated: Women after menopause can get the skin benefits of estrogen with topical preparations. Two of these studies done by Dr. Schmidt and colleagues, from the University of Vienna Medical School, Austria called Treatment of skin aging with topical estrogen studied the effects of topical estrogen treatment with 0.01% estradiol or 0.3% estriol in 59 postmenopausal women. After 6 month of treatment, a marked improvement in skin elasticity and firmness was noted; wrinkle depth and pore size decreased by 61 and 100 percent in estradiol and estriol group, respectively. Skin moisture and collagen synthesis increased significantly.

The skin is a reflection of our bones. If we have a tendency to lose collagen in our skin, the same will occur in our bones. Hormone replacement therapy significantly decreases reductions in skin elasticity that accompany menopause. It has been shown in studies that skin tensile strength parameters are significantly more favorable in the HRT group than the no-HRT groups. Pale, fine-skinned white women, especially if they are thin, who suffer significant skin loss changes in menopause are undergoing similar bone loss with the development of osteoporosis.

Collagen maintenance doesn't come in the form of creams, facials, or plastic surgery. Hormone replacement therapy (HRT) alone increases collagen production after menopause.

Abstracts:

Measurement of skin thickness by high-frequency ultrasound to objectify the effects of hormone replacement therapy in the Perimenopause Ultraschall Med 2001 Oct;22(5):219-24

Treatment of skin aging with topical estrogens Int J Dermatol 1996 Sep;35(9)669-74

Treatment of skin aging symptoms in perimenopausal females with estrogen compounds. A pilot study. Maturitas 1994 nov;20(1):25-30

HRT May Slow Menopausal Loss of Skin Elasticity - Internal Medicine News January 1, 2002/Volume 35/ Number 1

Sexual Relationships -For some women, freedom from birth control and freedom from worries regarding unwanted pregnancy releases long-held inhibitions. Sex becomes freer, more spontaneous, and more enjoyable.

For others, physical changes including reduced lubrication, thinning of the vaginal walls, and reduced levels of hormones, reduces sexual desire or interest. Reduced frequency of intercourse can result in further thinning of the vagina and in reduced elasticity - which may ultimately lead to pain during intercourse - which further reduces sexual desire. To avoid or reduce the incidence of these problems, try some of the many lubrication products on the market and find one that works for you and your partner. If you have pain during intercourse, visit your doctor. Consider HRT as an option.
Sleeplessness/Insomnia/Fatigue - Nearly 40 percent of mid-life women say they have insomnia - double the percentage from premenopausal days. Most often, insomnia or sleeplessness is a consequence of nighttime hot flashes, which interrupt REM sleep. Estrogen deprivation may also increase wakefulness without any loss of temperature control.
Fatigue and low energy are another domino effect of hot flashes and poor sleep Irritability, nervousness, memory lapses, and difficulties concentrating may also occur. While mood swings and depression may be linked to hormonal changes, they are most likely due to the effects of insomnia and sleep deprivation. Recent studies have shown that when mid-life men are subjected to sleep interruption, they exhibit the same signs of stress as mid-life women, becoming irritable, short-tempered, moody and tired.

Abstracts:

When does estrogen replacement therapy improve sleep quality? Am J Obstet Gynecol 1998 May;178(5)1002-

Effect of short-term transdermal estrogen replacement therapy on sleep: a randomized, double-blind crossover trial in postmenopausal women.
Fertil Steril 1999 May;71(5):873-80

Poor Memory and Loss of Concentration - Delayed reactions, a slowdown in knowledge retrieval, trouble remembering simple things, and vague unfocused feelings have been attributed to menopause. Short-term memory is more often affected than long-term memory.
Poor concentration during menopause can be partially attributed to lack of sleep due to night sweats, however, women who have undergone a sudden, medically induced menopause, report alarming degrees of forgetfulness. The more sudden the estrogen deprivation, the greater the symptoms.

Women who receive Hormone Replacement Therapy (HRT) report that concentration and memory improve almost immediately.

Abstracts:

Effects of estrogen on congnition mood, and degenerative brain diseases. J Am Pharm Assoc (Wash) 2001 Mar-Apr, 41(2)221-8

Long-term estrogen replacement is associated with improved nonverbal memory and attentional measures in postmenopausal women. Fertil Steril 2001 Dec;76(6):1101-7

Two weeks of transdermal estradiol treatment in postmenopausal elderly women and its effect on memory and mood: verbal memory changes are associated with the treatment induced estradiol levels. Psychoneuroendocrinology 199 Oct;24(7):727


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Disclaimer: The information contained on this website has not been evaluated by the FDA. This information is not intended to treat, diagnose, cure or prevent any disease. All material provided in the Dr. Brizel's web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.


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