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Premenstrual
Syndrome (PMS) & Premenstrual Dysphoric Disorder (PDD)
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| Premenstrual
Syndrome (PMS) & Premenstrual Dysphoric Disorder (PDD) -
Diagnosis |
PMS is diagnosed after other medical conditions or psychiatric conditions
(hypothyroidism or depression) have been ruled out. Work up at our
center includes CBC, electrolyte, TSH, Free T3, Free T4, estradiol
and progesterone levels on day 21 of the menses charting from two
menstrual cycles. PDD is a more severe form of PMS with more prominent
mood symptoms.
The cause of PMS remains unclear still. While some research have linked
the psychological and behavior symptoms to a decline in circulating
progesterone. Evidence of a strong relationship between GABA and Progesterone
being directed linked thus when progesterone levels fall GABA declines
leading to anxiety and PMS. While other consensus opinions state that
there is no abnormal ovarian axis function. Rather what these women
experience is abnormal. They have a predisposition or sensitivity
to the normal cycle hormonal changes that occur during the menstrual
cycle. The cause appears to be a very complex multifactor psychoneuroendocologic
interaction that seems to be prompted by ovulation
| Premenstrual
Syndrome (PMS) & Premenstrual Dysphoric Disorder (PDD) |
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